胆汁酸 药物吸收
Increased intestinal bile acid reabsorption and reduced intestinal bile acid efflux may result in increased intestinal bile acid content and total bile acid pool size in DKO mice.
精选增加的肠胆汁酸重吸收和减少的肠胆汁酸流出可能导致DKO小鼠中肠胆汁酸含量和总胆汁酸池大小增加。
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结果来源论著2019IF 14.7Hepatology
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Excessive production of some bile acids and bile acid malabsorption can lead to overabundance of bile acids, which is a hallmark of IBD, although the exact mechanisms remain unknown.
精选一些胆汁酸的过量产生和胆汁酸吸收不良可导致胆汁酸过量，这是IBD的标志，尽管确切的机制仍然未知。
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结果来源论著2019IF 30.8Nature Methods
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Treatment with bile acid binding medications is effective in patients with bile-acid malabsorption but can also be effective in patients without bile-acid malabsorption.
胆汁酸结合药物治疗对胆汁酸吸收不良的患者有效，但对无胆汁酸吸收不良的患者也有效。
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引言来源论著2012IF 3.7World Journal of Gastroenterology
Bile acid binding agents may impair the absorption of some co-medications.
胆汁酸结合剂可损害一些辅助药物的吸收。
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结果来源综述2016IF 3.7World Journal of Gastroenterology
Recent data showed bile acids were involved in the solubilization and absorption of lipophilic drugs.
最近的数据显示胆汁酸参与亲脂性药物的溶解和吸收。
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结果来源综述2018IF 7.7British Journal of Pharmacology
“语境”功能：原文中本句所处在的段落的情况，通过”语境”功能，能更好理解本句的前后文和使用语境。（备注: 如果语境中只出现了本句，说明本句在原文中自成一小段。）
标题Secondary effects of drugs on the gut microbiome
Studies have found a correlation between the reduced levels of SCFAs in the proximal to distal colon with the corresponding increase in pH from the caecum to rectum.
研究发现，近端至远端结肠中的scfa水平降低与盲肠至直肠的pH相应增加之间存在相关性。
Cefoperazone, vancomycin and clindamycin were identified as antibiotics associated with changes in the gut microbiota composition and caused decreased levels of secondary bile acids precipitating the growth and spore germination of C. difficile.
头孢哌酮、万古霉素和克林霉素被鉴定为与肠道微生物群组成的变化相关的抗生素，并导致沉淀艰难梭菌生长和孢子萌发的次级胆汁酸水平降低。
Drug treatment can, however, alter the gut microbiota production of bile salts, which may subsequently affect the absorption and metabolism of co‐administered medication.
然而，药物治疗可以改变胆汁盐的肠道菌群产生，这可能随后影响共同施用药物的吸收和代谢。
The liver is continually exposed to gut microbiota‐derived metabolites, including secondary bile acids and short chain fatty acids (SCFAs), as it receives an estimated 70% of its blood supply from the intestine.
肝脏持续暴露于肠道微生物衍生的代谢物，包括次级胆汁酸和短链脂肪酸 (SCFAs)，因为它从肠道接收估计70% 的血液供应。
Recent data showed bile acids were involved in the solubilization and absorption of lipophilic drugs.
本句最近的数据显示胆汁酸参与亲脂性药物的溶解和吸收。
Drug‐induced changes in the production of SCFAs could thus indirectly alter GI pH, which as mentioned previously may precipitate changes in the microbiome.
药物诱导的SCFAs产生的变化因此可以间接改变GI pH，如前所述，这可能会导致微生物组的变化。
For example, increased levels of SCFAs were linked with metformin, which could instigate the microbiota modifications associated with this drug.
例如，增加的scfa水平与二甲双胍相关，其可引发与该药物相关的微生物群修饰。
This is the major mechanism of bile acid re-absorption feedback inhibition of bile acid synthesis.
这是胆汁酸重吸收反馈抑制胆汁酸合成的主要机制。
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结果来源综述2016IF 3.7World Journal of Gastroenterology
Bile acid sequestrants, another class of cholesterol-lowering drugs, also inhibit cholesterol absorption, as well as bile acid reabsorption.
胆汁酸螯合剂，另一类降胆固醇药物，也抑制胆固醇吸收，以及胆汁酸重吸收。
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引言来源论著2013IF 5.0Faseb Journal
Intestinal bile acid absorption was increased and accompanied by increases in plasma bile acid levels, biliary bile acid secretion and enterohepatic cycling of bile acids.
肠胆汁酸吸收增加，并伴随着血浆胆汁酸水平、胆汁胆汁酸分泌和胆汁酸的肠肝循环的增加。
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摘要来源论著2015IF 20.6Journal of Hepatology
These resins bind bile acids in the intestinal lumen and consequently impair bile acid resorption, thus interrupting the enterohepatic circulation of bile acids.
这些树脂在肠腔中结合胆汁酸并因此损害胆汁酸再吸收，从而中断胆汁酸的肠肝循环。
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结果来源综述2013IF 21.6Cell Metabolism
The human ileal bile acid transporter, also known as hASBT (SLC10A2), is a key component in the enterohepatic recirculation of bile acids and serves as a target to enhance oral drug absorption.
人回肠胆汁酸转运蛋白，也称为hASBT (SLC10A2)，是胆汁酸肠肝再循环的关键组分，并作为增强口服药物吸收的靶标。
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讨论来源论著2006IF 4.3Molecular Pharmaceutics
Fig. 7. GG elevates plasma bile acid levels likely by promoting bile acid reabsorption.
图7. GG可能通过促进胆汁酸重吸收来提高血浆胆汁酸水平。
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图注来源论著2017IF 4.5Journal of Lipid Research
Intestinal bile acids can be absorbed by bile acid binding resin (BAR) and likely improve obesity and metabolic disorders.
肠胆汁酸可以被胆汁酸结合树脂 (BAR) 吸收，并可能改善肥胖和代谢紊乱。
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结果来源综述2018IF 3.3Journal of Immunology Research
While absorption of bile acids in proximal small intestine does not result in alterations in faecal bile acid excretion, overall pool size (figure 4a), BW and plasma triglyceride or cholesterol levels, our data show that proximal absorption of bile acids results in TBMC enrichment of the bile acid pool (figure 4b).
虽然近端小肠吸收胆汁酸不会导致粪便胆汁酸排泄、总胆汁酸池大小 (图4a) 、BW和血浆甘油三酯或胆固醇水平的改变，但我们的数据显示，胆汁酸的近端吸收导致胆汁酸池的TBMC富集 (图4b)。
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讨论来源论著2010IF 19.8Gut
Figure 1. The enterohepatic circulation of bile acids. The various steps in bile acid synthesis, secretion, absorption and resecretion are indicated.
图1.胆汁酸的肠肝循环。说明胆汁酸合成、分泌、吸收和再吸收的各个步骤。
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图注来源论著2010IF 3.5Therapeutic Advances in Gastroenterology
This review provides in-depth insight into the mechanisms of drug absorption enhancement mediated by bile acids, but also into the molecular interactions between drugs and bile acids that can impact absorption and pharmacokinetic properties of drug molecules.
本综述深入探讨了胆汁酸介导的药物吸收增强机制，也深入探讨了药物与胆汁酸之间的分子相互作用，这些相互作用会影响药物分子的吸收和药代动力学性质。
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讨论来源综述2018IF 4.2Frontiers in Pharmacology
Bile acid sequestrants bind bile acids in the intestine to prevent bile acid reabsorption, thus reducing the bile acid pool size.
胆汁酸螯合剂在肠道内结合胆汁酸，阻止胆汁酸重吸收，从而减小胆汁酸池大小。
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结果来源综述2019IF 3.1Diabetes & Metabolism Journal
This transporter may also be employed as a prodrug target for enhancing oral drug bioavailability of poorly permeating compounds, where drug is conjugated to bile acid and bile acid allows for the conjugate to be taken up by ASBT.
该转运蛋白也可用作前药靶标，用于增强低渗透性化合物的口服药物生物利用度，其中药物与胆汁酸缀合，并且胆汁酸允许缀合物被ASBT吸收。
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引言来源论著2010IF 4.0Bioconjugate Chemistry
An alternative strategy to providing supplemental bile acids is to inhibit reabsorption of native bile acids in the terminal ileum.
提供补充胆汁酸的替代策略是抑制末端回肠中天然胆汁酸的重吸收。
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结果来源综述2014IF 3.0Journal of Neurogastroenterology and Motility
After intestinal reabsorption, bile acids enter enterohepatic circulation, with up to 15 circulations per bile acid per day.
肠重吸收后，胆汁酸进入肠肝循环，每天每胆汁酸最多循环15次。
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引言来源论著2012IF 7.9Journal of Nuclear Medicine
Genetic knockout of Asbt in mice interrupts enterohepatic circulation of bile acids and causes bile acid malabsorption.
小鼠中Asbt的基因敲除中断胆汁酸的肠肝循环并导致胆汁酸吸收不良。
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结果来源综述2009IF 4.5Journal of Lipid Research
Bile acids or their salts form nanomicelles with fatty acids as drug carriers, which promote drug absorption.
胆汁酸或其盐与脂肪酸作为药物载体形成纳米胶束，促进药物吸收。
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引言来源论著2015IF 5.1International Journal of Nanomedicine
Bile acids are reabsorbed into enterocytes by the apical sodium-dependent bile acid transporter (Asbt).
胆汁酸通过顶端钠依赖性胆汁酸转运蛋白 (Asbt) 被重吸收到肠细胞中。
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引言来源论著2016IF 3.3Toxicology and Applied Pharmacology
Ninety-five percent of bile acids are reabsorbed in the lower small intestine by the apical sodium-dependent bile acid transporter (ASBT).
95% 的胆汁酸在小肠下部被顶端钠依赖性胆汁酸转运蛋白 (ASBT) 重吸收。
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引言来源论著2015IF 3.9Endocrinology
The human ileal bile acid transporter, also known as hASBT (SLC10A2), is a key component in the enterohepatic recirculation of bile acids, as well as a target for enhanced oral drug absorption.
人回肠胆汁酸转运蛋白，也称为hASBT (SLC10A2)，是胆汁酸肠肝再循环的关键组分，也是增强口服药物吸收的靶标。
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引言来源论著2006IF 3.2Pharmaceutical Research
Interruptions of bile flow, reduction of intestinal bile acid absorption, or defects of bile acid metabolism can induce severe disease.
胆汁流动的中断、肠胆汁酸吸收的减少或胆汁酸代谢的缺陷可诱发严重的疾病。
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讨论来源论著2010IF 4.5Journal of Lipid Research
Absorbed bile acids enter into the portal bloodstream and are rapidly taken up by hepatocytes and resecreted into bile.
被吸收的胆汁酸进入门脉血流并被肝细胞迅速吸收并重新注入胆汁。
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结果来源综述2020IF 7.7Gut Microbes
Bile acid diarrhea results from excessive amounts of bile acids entering the colon due to hepatic overexcretion of bile acids or bile acid malabsorption in the terminal ileum.
胆汁酸腹泻是由于末端回肠中胆汁酸的肝脏过度排泄或胆汁酸吸收不良而导致过量的胆汁酸进入结肠。
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摘要来源病例报道2018IF 3.7World Journal of Gastroenterology
Each individual bile salt has an input, either de novo synthesis for primary bile acids and alcohols or intestinal absorption for newly formed secondary bile acids.
每个单独的胆汁盐具有输入，初级胆汁酸和醇的从头合成或新形成的次级胆汁酸的肠吸收。
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引言来源综述2010IF 4.5Journal of Lipid Research
Alternatively, loperamide, a drug used to reduce diarrhea, results in slower transit time and increases bile acid reabsorption, reducing primary bile acid concentrations in the feces.
或者，洛哌丁胺 (一种用于减少腹泻的药物) 导致更慢的转运时间并增加胆汁酸重吸收，降低粪便中的初级胆汁酸浓度。
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讨论来源论著2019IF 4.1Frontiers in Cellular and Infection Microbiology
It is possible that the high fiber content of rose hip impairs the enterohepatic circulation of bile acids by preventing their re-absorption, thereby promoting increased synthesis of bile acids from cholesterol, that is, a mechanism of action similar to that of the cholesterol-lowering drug cholestyramin.
可能玫瑰果的高纤维含量通过阻止胆汁酸的再吸收而损害胆汁酸的肠肝循环，从而促进胆固醇合成胆汁酸的增加，即类似于降胆固醇药物胆固醇酯的作用机制。
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讨论来源RCT2012IF 3.3European Journal of Clinical Nutrition
Plasma bile acid levels are influenced by a number of variables, including hepatic bile acid synthesis and ileal bile acid reabsorption efficiency.
血浆胆汁酸水平受许多变量的影响，包括肝胆汁酸合成和回肠胆汁酸重吸收效率。
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讨论来源论著2011IF 17.4Gastroenterology
Ileal diseases and resections result in bile acid malabsorption due to loss of intestinal bile acid transport capacity.
回肠疾病和切除由于肠道胆汁酸转运能力的丧失而导致胆汁酸吸收不良。
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引言来源论著2010IF 19.8Gut
FXR influences bile acid flux via various feedforward and feedback loops, modulating bile acid synthesis, modification, absorption and uptake.
FXR通过各种前馈和反馈回路影响胆汁酸通量，调节胆汁酸合成、修饰、吸收和摄取。
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结果来源综述2012IF 55.5Nature Reviews Molecular Cell Biology
A failure to reabsorb bile acid was also suggested to be a cause of diarrhea owing to excess bile acids entering the colon.
由于过量的胆汁酸进入结肠，再吸收胆汁酸的失败也被认为是腹泻的原因。
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引言来源论著2017IF 3.0Journal of Neurogastroenterology and Motility
Thus, there is uptake of bile acids into breast tissue.
因此，胆汁酸被吸收到乳腺组织中。
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讨论来源论著2019IF 10.1Clinical Cancer Research
Bile acid malabsorption (BAM) results in excess fecal bile acids that can cause chronic diarrhea and other colon pathology.
胆汁酸吸收不良 (BAM) 导致过量的粪便胆汁酸，其可引起慢性腹泻和其他结肠病理。
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引言来源论著2013IF 3.2Pharmaceutical Research
Their capability of taking up bile acids or to express genes involved in bile acid transport and metabolism in a physiological and stable level validates the model for research in other important areas of hepatology, including drug-induced liver injury (DILI).
它们吸收胆汁酸或以生理和稳定水平表达参与胆汁酸转运和代谢的基因的能力验证了该模型在肝病其他重要领域的研究，包括药物诱导的肝损伤 (DILI)。
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结果来源综述2019IF 5.1Hepatology International
Reabsorbed bile acids enter hepatic portal circulation.
重吸收的胆汁酸进入肝门循环。
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结果来源综述2018IF 3.3Journal of Immunology Research
The decreased expression of FXR leads also to a reduction in SHP inhibition of bile acid absorption, bile acid reabsorption is increased, and excretion is reduced.
FXR表达的降低也导致SHP抑制胆汁酸吸收的减少，胆汁酸重吸收增加，排泄减少。
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图注来源论著2014IF 5.0Faseb Journal
In the distal ileum, bile acid absorption from the lumen occurs via ASBT and bile acid efflux out of the cell via OSTα / OSTβ.
在远端回肠中，胆汁酸通过ASBT从管腔吸收，胆汁酸通过OSTα/OSTβ 从细胞流出。
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结果来源综述2018IF 4.2Frontiers in Pharmacology
Dietary fat affects bile acid metabolism, because the absorption of fat requires an increase in bile flow.
膳食脂肪影响胆汁酸代谢，因为脂肪的吸收需要增加胆汁流量。