Omega 3 fatty acids chemosensitize multidrug resistant colon cancer cells by
down-regulating cholesterol synthesis and altering detergent resistant membranes composition. Omega3脂肪酸通过下调胆固醇合成和改变DRM成分，增加多药耐药结肠癌细胞化学敏感性
The activity of P-glycoprotein (Pgp) and multidrug resistance related protein 1 (MRP1), two membrane transporters involved in multidrug resistance of colon cancer, is increased by high amounts of cholesterol in plasma membrane and detergent resistant membranes (DRMs). It has never been investigated whether omega 3 polyunsatured fatty acids (PUFAs), which modulate cholesterol homeostasis in dyslipidemic syndromes and have chemopreventive effects in colon cancer, may affect the response to chemotherapy in multidrug resistant (MDR) tumors.
糖蛋白(P-glycoprotein，Pgp)和多药耐药性相关蛋白1(re洗涤剂相关蛋白1，MRP1)是参与结肠癌多药耐药性的两种膜转运蛋白，它们的活性通过质膜和耐洗涤剂膜中大量的胆固醇而增加。Ω3多不饱和脂肪酸(PUFAs)调节血脂紊乱综合征中的胆固醇平衡，对结肠癌具有化学预防作用，是否可能影响多药耐药(MDR)肿瘤的化疗反应，目前尚未有研究。