题目：
Methoxychlor exposure induces oxidative stress and affects mouse oocyte meiotic maturation
甲氧氯暴露诱导氧化应激并影响小鼠卵母细胞减数分裂成熟
句子翻译：
Methoxychlor (MXC) is used worldwide against insects and other pests. This organochlorine
pesticide acts as a xenoestrogen, promotes oxidative stress, and is considered cytotoxic and
genotoxic, causing abortions and stillbirths in females. Mechanistically related estrogens and
oxidants affect oocyte meiosis, so we investigated the effects of MXC on mouse oocyte meiotic maturation. Our results showed that maturation rates of MXC-treated oocytes treated were lower than those of controls, which was due to abnormal spindle morphologies and DNA double-strand breaks, as confirmed by increased γ-H2AX foci. Our findings also suggest that MXC may affect oocyte quality by causing excessive accumulation of superoxide radicals and other reactive oxygen species, aberrant mitochondrial distribution, decreased mitochondrial membrane potential, and increased lipid peroxidation. Thus, exposure to MXC negatively affects oocyte meiotic maturation,primarily through impairments in cellular ROS metabolism.
摘要：甲氧氯（MXC）在全世界范围内被用来对付昆虫和其他害虫。这种有机氯杀虫剂是一种异种雌激素，促进氧化应激，并被认为具有细胞毒性和基因毒性。机制上相关的雌性激素和氧化剂影响卵母细胞减数分裂，因此我们研究了MXC对小鼠卵母细胞减数分裂成熟的影响。我们的结果显示，经MXC处理的卵母细胞的成熟率低于对照组，这是由于纺锤体形态异常和DNA双链断裂造成的，这一点被γ-H2AX病灶的增加所证实。我们的研究结果还表明，MXC可能通过引起超氧自由基和其他活性氧的过度积累、线粒体分布异常、线粒体膜电位下降和脂质过氧化增加而影响卵母细胞质量。因此，暴露于MXC对卵母细胞减数分裂成熟有负面影响，主要是通过细胞ROS代谢的损害。
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