【文献速递】【NBT】【2022年】【7-12月】

声明:本专栏主要对生命科学领域的一些期刊文章标题进行翻译,所有内容均由本人手工整理翻译。由于本人专业为生物分析相关,其他领域如果出现翻译错误请谅解。

1.Smartphone apps in the COVID-19 pandemic.

COVID-19大流行中的智能手机应用程序。

2.SignalP 6.0 predicts all five types of signal peptides using protein language models.

SignalP 6.0使用蛋白质语言模型预测所有五种类型的信号肽。

3.Fast nanopore sequencing data analysis with SLOW5.

使用SLOW5进行快速纳米孔测序数据分析。

4.Mitochondrial variant enrichment from high-throughput single-cell RNA sequencing resolves clonal populations.

来自高通量单细胞RNA测序的线粒体变异富集解决了克隆群体。

5.Accelerated identification of disease-causing variants with ultra-rapid nanopore genome sequencing.

通过超快纳米孔基因组测序加速鉴定引起疾病的变体。

6.Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.

源自干细胞的人胰岛的功能、代谢和转录成熟。

7.A comparison of experimental assays and analytical methods for genome-wide identification of active enhancers.

对活性增强子的全基因组鉴定的实验测定和分析方法的比较。

8.CoSpar identifies early cell fate biases from single-cell transcriptomic and lineage information.

COSPAR确定了单细胞转录组和谱系信息的早期细胞命运偏差。

9.Multiplex de Bruijn graphs enable genome assembly from long, high-fidelity reads.

多重de Bruijn图可从长长的高保真读取中启用基因组组件。

10.Single-nuclei isoform RNA sequencing unlocks barcoded exon connectivity in frozen brain tissue.

单核同工型RNA测序解锁冷冻脑组织中的条形码外显子连接。

11.Endogenous ADAR-mediated RNA editing in non-human primates using stereopure chemically modified oligonucleotides.

内源性ADAR介导的RNA编辑在非人类灵长类动物中使用立体纯化学修饰的寡核苷酸。。

12.Synthetic introns enable splicing factor mutation-dependent targeting of cancer cells.

合成内含子可以实现剪接因子突变依赖性癌细胞的靶向。

13.Learning protein fitness models from evolutionary and assay-labeled data.

从进化和测定标记的数据中学习蛋白质适应度模型。

14.Designing sensitive viral diagnostics with machine learning.

通过机器学习设计敏感的病毒诊断。

15.A highly photostable and bright green fluorescent protein.

高度光稳定且明亮的绿色荧光蛋白。

16.Computationally designed dual-color MRI reporters for noninvasive imaging of transgene expression.

计算设计的双色MRI报告子用于转基因表达的非侵入性成像。

1.Spatial charting of single-cell transcriptomes in tissues.

组织中单细胞转录组的空间图表。

2.Integrative spatial analysis of cell morphologies and transcriptional states with MUSE.

使用MUSE对细胞形态和转录状态的整合空间分析。

3.m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome.

在单基碱分辨率下测量整个哺乳动物转录组的M6A RNA修饰。

4.Characterizing cellular heterogeneity in chromatin state with scCUT&Tag-pro.

用scCUT和Tag-pro表征染色质状态的细胞异质性。

5.Deep Visual Proteomics defines single-cell identity and heterogeneity.

深视觉蛋白质组学定义了单细胞的身份和异质性。

6.In vivo engineered B cells secrete high titers of broadly neutralizing anti-HIV antibodies in mice.

体内工程的B细胞在小鼠中分泌高滴定度的广泛中和抗HIV抗体。

7.Bioinstructive implantable scaffolds for rapid in vivo manufacture and release of CAR-T cells.

用于快速在体内生产和释放CAR-T细胞的生物学结构可植入的支架。

8.A programmable encapsulation system improves delivery of therapeutic bacteria in mice.

可编程封装系统改善了治疗性细菌在小鼠体内的输送。

9.Efficient discovery of SARS-CoV-2-neutralizing antibodies via B cell receptor sequencing and ligand blocking.

通过B细胞受体测序和配体阻断有效发现SARS-COV-2中和抗体。

10.Accurate detection of tumor-specific gene fusions reveals strongly immunogenic personal neo-antigens.

肿瘤特异性基因融合的准确检测显示出强烈的免疫原性的个人新抗原。

11.Fludarabine increases nuclease-free AAV- and CRISPR/Cas9-mediated homologous recombination in mice.

氟达拉滨增加了小鼠中无核酸酶AAV和CRISPR/CAS9介导的同源重组。

1.Haplotype-resolved assembly of diploid genomes without parental data.

没有父母数据的二倍体基因组的单倍型解析组装。

2.Thermodynamically coupled biosensors for detecting neutralizing antibodies against SARS-CoV-2 variants.

热力学耦合生物传感器,用于检测针对SARS-CoV-2变体的中和抗体。

3.A genome and gene catalog of glacier microbiomes.

冰川微生物组的基因组和基因目录。

4.Spatially informed cell-type deconvolution for spatial transcriptomics.

空间转录组学的空间信息的细胞类型反卷积。

5.DestVI identifies continuums of cell types in spatial transcriptomics data.

DESTVI在空间转录组学数据中识别细胞类型的连续体。

6.Generation of a live attenuated influenza A vaccine by proteolysis targeting.

通过蛋白水解靶向产生活体流感A疫苗。

7.CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA.

无CRISPR基础编辑者具有增强的活性并扩大了线粒体和核DNA的靶向范围。

8.A split prime editor with untethered reverse transcriptase and circular RNA template.

具有不受束缚的逆转录酶和圆形RNA模板的拆分主编辑器。

9.An engineered prime editor with enhanced editing efficiency in plants.

工程的引导编辑器具有增强的植物编辑效率。

10.Targeting a gene regulatory element enhances rice grain yield by decoupling panicle number and size.

靶向基因调节元件可通过解耦穗数和大小来增强水稻颗粒的产量。

1.Assessing the efficiency of Verily’s automated process for production and release of male Wolbachia-infected mosquitoes.

评估雄性沃尔巴契亚感染蚊子的生产和释放的自动化过程的效率。

2.Reply to: Assessing the efficiency of Verily’s automated process for production and release of male Wolbachia-infected mosquitoes.

回复:评估雄性沃尔巴契亚感染蚊子的生产和释放的自动化过程的效率。

3.Fast and highly sensitive full-length single-cell RNA sequencing using.

使用FLASH-seq进行快速且高度敏感的全长单细胞RNA测序。

4.Scalable single-cell RNA sequencing from full transcripts with Smart-seq3xpress.

用Smart-Seq3xpress的完整转录本的可扩展单细胞RNA测序。

5.Multi-omics single-cell data integration and regulatory inference with graph-linked embedding.

多组学单细胞数据集成和图链接嵌入的监管推断。

6.DIALOGUE maps multicellular programs in tissue from single-cell or spatial transcriptomics data.

DIALOGUE映射单细胞或空间转录组数据的组织中的多细胞程序。

7.Comparison and imputation-aided integration of five commercial platforms for targeted DNA methylome analysis.

用于靶向DNA甲基化组分析的五个商业平台的比较和插补辅助整合。

8.Identifying synergistic high-order 3D chromatin conformations from genome-scale nanopore concatemer sequencing.

从基因组尺度纳米多联体测序中鉴定出协同的高阶3D染色质构象。

9.Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates.

用亲脂性结合物扩展RNAi疗法到肝外组织。

10.Logic-gated antibody pairs that selectively act on cells co-expressing two antigens.

逻辑门控抗体对有选择地作用于共表达两种抗原的细胞。

11.Prediction of protein–ligand binding affinity from sequencing data with interpretable machine learning.

通过可解释的机器学习来测序数据的蛋白质 – 配体结合亲和力的预测。

1.Unlocking the promise of mRNA therapeutics.

解锁mRNA疗法的承诺。

2.Directed evolution and selection of biostable L-DNA aptamers with a mirror-image DNA polymerase.

具有镜像DNA聚合酶的可生物固定L-DNA适体的定向演化和选择。

3.Transplantation of a human liver following 3 days of ex situ normothermic preservation.

在原位正常温度保存3天后,人肝移植。

4.Single-sequence protein structure prediction using a language model and deep learning.

单序蛋白结构使用语言模型和深度学习预测。

5.Estimation of tumor cell total mRNA expression in 15 cancer types predicts disease progression.

肿瘤细胞总mRNA表达15种癌症类型的估计预测疾病进展。

6.Genome-wide mapping of somatic mutation rates uncovers drivers of cancer.

体细胞突变率的全基因组映射发现了癌症的驱动因素。

7.Variant to function mapping at single-cell resolution through network propagation.

通过网络传播在单细胞分辨率下函数映射的变体。

8.Spatiotemporal multiplexed immunofluorescence imaging of living cells and tissues with bioorthogonal cycling of fluorescent probes.

活细胞和组织的时空多重免疫荧光成像,具有荧光探针的生物正交循环。

9.Deep tissue multi-photon imaging using adaptive optics with direct focus sensing and shaping.

深层组织多光子成像使用具有直接焦点传感和塑形的自适应光学器件。

10.A red light–responsive photoswitch for deep tissue optogenetics.

用于深层组织光遗传学的红光响应光电开关。

11.Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR.

全血PCR对SARS-COV-2细胞免疫的快速,可扩展的评估。

1.Enhancing untargeted metabolomics using metadata-based source annotation.

使用基于元数据的源注释来增强非靶向代谢组学。

2.High-throughput total RNA sequencing in single cells using VASA-seq.

使用VASA-seq在单细胞中进行高通量总RNA测序。

3.High-plex imaging of RNA and proteins at subcellular resolution in fixed tissue by spatial molecular imaging.

通过空间分子成像在固定组织中的亚细胞分辨率下的RNA和蛋白质的高复合成像。

4.Frequent aneuploidy in primary human T cells after CRISPR–Cas9 cleavage.

CRISPR – CAS9裂解后原代人T细胞中频繁的非整倍性。

5.Viral variant-resolved wastewater surveillance of SARS-CoV-2 at national scale.

在国家范围内对SARS-CoV-2进行病毒变体解析的废水监测。

6.A multiplex implantable microdevice assay identifies synergistic combinations of cancer immunotherapies and conventional drugs.

多重植入式微装置分析可以确定癌症免疫疗法和常规药物的协同组合。

7.Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice.

RAS突变癌对小鼠V型ATP酶的小分子抑制敏感。

8.The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants.

三特异性DARPin恩索维普抑制了不同的SARS-CoV-2变体。

9.Rapid biosensor development using plant hormone receptors as reprogrammable scaffolds.

植物激素受体作为可重新编程的支架用于快速生物传感器开发。

10.Synthetic memory circuits for stable cell reprogramming in plants.

合成记忆电路,用于植物中稳定的细胞重编程。

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